The surest sign that the players always regarded PED use as unethical was, and is, the secrecy surrounding it. A pitcher gets a cortisone shot for his sore shoulder, it's known. Same pitcher gets human growth hormone for the same injury, he's not letting anybody know it.
Here, from the Chicago Sun-Times, is a first-person account of his own big why from Jim Parque, who went 31-34 over six major league seasons around the turn of the millennium, mostly with the White Sox.
And here is a piece on the reaction from the White Sox clubhouse. Ozzie Guillen's comment ... well, that's Ozzie.